Nisoxetine Hydrochloride | Neurotransmitter Transporters | Noradrenaline Re-uptake Inhibitor

Category:

Cat.No.	Product Name
1025	Nisoxetine hydrochloride

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Nisoxetine hydrochloride

Chemical Name: (±)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride

Biological Activity:

A potent and selective inhibitor of noradrenaline uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data:

M.Wt:	307.82
Formula:	C₁₇H₂₁NO₂.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water
Purity:	>99%
CAS No:	[57754-86-6]

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Certificate of Analysis / MSDS:

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References:

Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart. Life Sci. 17 755. Cheetham et al (1996) [³H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [³H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63. Zhu et al (1997) Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134. Shearman and Meyer (1998) Norepinephrine transporters in rat placenta labeled with [³H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736.

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Keywords: Nisoxetine Hydrochloride, Neurotransmitter Transporters, Noradrenaline Re-uptake Inhibitor, Tocris Bioscience

Literature in this Area

Scientific Reviews

Adrenoceptor Pharmacology
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Product Feature

Uptake Inhibitors

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