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Category:
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Ion Channels Potassium ChannelsATP-Activated Potassium Channels
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Cat.No.
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Product Name
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2147 |
Nicorandil
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Price and Availability
Click here for full price details of
Nicorandil
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Chemical Name:
N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide |
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Biological Activity:
KATP
channel opener and NO donor, clinically used as antianginal agent.
Preferentially activates SUR2B- versus SUR2A-containing KATP
channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold
increase in cardiac eNOS expression. Displays coronary and peripheral
vasodilatory properties, reduces both pre- and after-load, and increases
coronary blood flow. Also displays cardioprotective effects, possibly through
ischaemic preconditioning.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Shindo et al (1998) SUR2 subtype (A
and B)-dependent differential activation of the cloned ATP-sensitive K+
channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985. Horinaka
et al (2001) Nicorandil enhances cardiac endothelial nitric oxide
synthase expression via activation of adenosine triphosphate-sensitive K
channel in rat. J.Cardiovasc.Pharmacol. 38 200. Gomma et
al (2001) Potassium channel openers in myocardial ischaemia: therapeutic
potential of nicorandil. Drugs 61 1705.
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View related products by Pharmacological Action
or by Research Area
Keywords: Nicorandil, Potassium Channels, KATP Channel Opener & NO Donor, Tocris Bioscience
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