Synthetic gonadotropin-releasing hormone (GnRH)
agonist that stimulates secretion of luteinising hormone (LH) and
follicle-stimulating hormone (FSH). Repeated administration causes
desensitisation of pituitary GnRH receptors resulting in inhibition of
gonadotropin release and decreased steroid hormone synthesis. Induces atrophy
and regression of experimentally induced endometriosis in rat and shrinks
hypertrophic tissue in benign prostatic hyperplasia.
Chrisp and Goa (1990)
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clinical potential in sex hormone-related conditions. Drugs 39
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gonadotrophin-releasing hormone agonist for the treatment of endometriosis.
DICP. 24 1204. Mizutaniet al (1995) Effect of
gonadotrophin-releasing hormone agonists, nafarelin, buserelin, and leuprolide,
on experimentally induced endometriosis in the rat. Int.J.Fertil.Menopausal
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