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Category: EnzymesarrowKinasesarrowDNA-dependent Protein Kinase
Cat.No. Product Name
2828 NU 7026
Price and Availability

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NU 7026
Chemical Name: 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one

Biological Activity:

ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI 3-K, ATM and ATR respectively). Radiosensitises both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Technical Data:

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M.Wt: 281.31
Formula: C17H15NO3
Storage: Store at +4°C
Solubility: Soluble to 10 mM in DMSO
Purity: >98%
CAS No: [154447-35-5]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Hollick et al (2003) 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK). Bioorg.Med.Chem.Letts. 13 3083. Veuger et al (2003) Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I. Cancer Res. 63 6008. Amrein et al (2007) Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J.Pharmacol.Exp.Ther. 321 848.
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    Keywords: NU 7026, Kinases, Selective DNA-dependent Protein Kinase Inhibitor, NU7026, Tocris Bioscience
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