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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowKainate SelectivearrowAntagonists
Cat.No. Product Name
2187 NS 3763
Price and Availability

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NS 3763
Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid

Biological Activity:

Selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50 >> 30 μM).

Technical Data:

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M.Wt: 404.38
Formula: C22H16N2O6
Storage: Store at RT
Solubility: Soluble to 25 mM in DMSO
Purity: >98%
CAS No: [70553-45-6]

Resources:

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003.
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    Keywords: NS 3763, Ligand-gated Ion Channels, Selective Noncompetitive Kainate Antagonist; Selective For GLUK5, NS3763, Tocris Bioscience
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