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Category:
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Enzymes PhosphatasesPTP
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Cat.No.
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Product Name
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2613 |
NSC 87877
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Price and Availability
Click here for full price details of
NSC 87877
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Chemical Name:
8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfon
ic acid |
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Biological Activity:
Potent inhibitor of shp2 and shp1
protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355,
1.691, 7.745, 65.617, 84.473 and 150.930 μM
for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits
EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces
MDA-MB-468 cell viability/proliferation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Chen et
al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Mol.Pharmacol. 70 562. Zhao et al (2007) Regulation
of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67
1789. Redonde et al (2007) hTRPC1-associated alpha-actinin, and
not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
J.Thromb.Haemost. 5 2476.
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Keywords: NSC 87877, Phosphatases, Potent Inhibitor Of Shp2 & Shp1 PTP, NSC87877, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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