|
Category:
|
Cellular Processes and Components Signal TransductionG-proteins (small)
|
|
Cat.No.
|
Product Name
|
|
2161 |
NSC 23766
|
|
|
|
Price and Availability
Click here for full price details of
NSC 23766
|
|
Chemical Name:
N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-
4-pyrimidinyl]-2-methyl-4,6-quinolinediamine
trihydrochloride |
|
|
Biological Activity:
Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide
exchange factors (GEFs) TrioN and Tiam1
(IC50 ~ 50 μM) without affecting
Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and reported to
reverse tumour cell phenotyes in prostate cancer cells.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Gao et al (2004) Rational
design and characterization of a Rac GTPase-specific small molecule inhibitor.
Proc.Natl.Acad.Sci.USA 101 7618.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: NSC 23766, Signal Transduction, Selective Inhibitor Of Rac1-GEF Interaction; Antioncogenic, NSC23766, Tocris Bioscience
|
