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Category: Cellular Processes and ComponentsarrowSignal TransductionarrowCalcium SignallingarrowGeneral Calcium Signalling Agents
Cat.No. Product Name
0675 NPC 15199  
Price and Availability

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NPC 15199
Chemical Name: N-(9-Fluorenylmethoxycarbonyl)-L-leucine

Biological Activity:

Anti-inflammatory agent; increases intracellular Ca2+ levels.

Technical Data:

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M.Wt: 353.42
Formula: C21H23NO4
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
CAS No: [35661-60-0]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Burch et al (1991) N-(Fluorenyl-9-methoxycarbonyl) amino acids, a class of anti-inflammatory agents with a different mechanism of action. Proc.Natl.Acad.Sci.USA 88 355. Miller et al (1993) Guinea pig ileitis is attenuated by the leumidin N-(fluorenyl-9-methoxycarbonyl)leucine (NPC 15199). J.Pharmacol.Exp.Ther. 266 468. Jan et al (2000) NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. Chin.J.Physiol. 43 29.
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    Keywords: NPC 15199, Signal Transduction, Increases Intracellular Ca2+ Levels, NPC15199, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Mechanisms for Manipulating Intracellular Calcium Buffering
    Download PDF
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”
    Researcher, University of Pisa, Italy
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