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Category:
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7TM Receptors Dopamine ReceptorsD2-like ReceptorsD3-selective
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Cat.No.
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Product Name
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2635 |
NGB 2904
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Price and Availability
Click here for full price details of
NGB 2904
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Chemical Name:
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fl
uorene-2-carboxamide |
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Biological Activity:
Potent and selective dopamine D3
receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000,
> 10000 and > 10000 nM for D3, D2, 5-HT2,
α1,
D4, D1 and D5 receptors respectively).
Potently antagonises quinpirole-stimulated mitogenesis (IC50 = 6.8
nM). Attenuates cocaine's rewarding effects and inhibits relapse to
drug-seeking behaviour.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Yuan et al
(1998) NGB 2904 and NGB 2849: two highly selective dopamine D3
receptor antagonists. Bioorg.Med.Chem.Lett. 8 2715. Xi et
al (2006) The novel dopamine D3 receptor antagonist NGB 2904
inhibits cocaine's rewarding effects and cocaine-induced reinstatement of
drug-seeking behavior in rats. Neuropsychopharmacology 31 1393. Pritchard
et al (2007) The dopamine D3 receptor antagonist NGB 2904 increases
spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 86
718.
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View related products by Pharmacological Action
or by Research Area
Keywords: NGB 2904, Dopamine Receptors, Potent & Selective D3 Antagonist, NGB2904, Tocris Bioscience
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Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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