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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowP2X ReceptorsarrowAntagonists
Cat.No. Product Name
2548 NF 110
Price and Availability

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NF 110

Other Information:

 
Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis( carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt

Biological Activity:

High affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitising currents in rat DRG neurons (IC50 = 527 nM). Shows antitumour activity against several tumour types.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 1096.9
Formula: C41H28N6Na4O17S4
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
CAS No: [111150-22-2]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Dhar et al (2000) Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients. Eur.J.Cancer 36 803. Kassack et al (2004) Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur.J.Med.Chem. 39 345. Hausmann et al (2006) The suramin analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol.Pharmacol. 69 2058.
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    Keywords: NF 110, Ligand-gated Ion Channels, Potent P2X3 Antagonist, NF110, Tocris Bioscience
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