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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT2 ReceptorsarrowNon-selective 5-HT2
Cat.No. Product Name
2018 Mirtazepine
Alternative name(s): Org 3770
6-Azamianserin
Price and Availability

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Mirtazepine
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[ 2,3-c][2]benzazepine

Biological Activity:

Antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenaline (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Technical Data:

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M.Wt: 265.36
Formula: C17H19N3
Storage: Store at RT
Solubility: Soluble to 50 mM in Ethanol and to 20 mM in DMSO
Purity: >99%
CAS No: [85650-52-8]

Resources:

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    References:

    de Boer et al (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27 399. Kooyman et al (1994) Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 501. de Boer et al (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 277 852.
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    Keywords: Mirtazepine, 5-HT Receptors, Potent 5-HT2 Antagonist. Also 5-HT3, H1 & A2-antagonist. Antidepressant, Org 3770, 6-Azamianserin, Tocris Bioscience
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