Mibefradil | Calcium Channels | T-type Ca2+ Channel Blocker | Ro 40-5967

Category:

Ion Channels

Calcium Channels

Voltage-gated Calcium Channels

Cat.No.

Product Name

2198

Mibefradil dihydrochloride

Alternative name(s):

Ro 40-5967

Mibefradil C29H38FN3O3.2HCl (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride

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Mibefradil

Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamin o]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)- 2-naphthalenyl methoxyacetoacetate dihydrochloride

Biological Activity:

Ca²⁺ channel blocker with moderate selectivity for T-type Ca²⁺ channels displaying IC₅₀ values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.

Technical Data:

M.Wt:	568.56
Formula:	C₂₉H₃₈FN₃O₃.2HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 50 mM in Water
Purity:	>98%
CAS No:	[116644-53-2]

Resources:

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References:

Osterrieder and Holck (1989) In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. J.Cardiovasc.Pharmacol. 13 754. Veniant et al (1991) Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine. J.Cardiovasc.Pharmacol. 18 Suppl 10 S55. Mehrke et al (1994) The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J.Pharmacol.Exp.Ther. 271 1483.

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Keywords: Mibefradil, Calcium Channels, T-type Ca2+ Channel Blocker, Ro 40-5967, Tocris Bioscience

Literature in this Area

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