4-Methylhistamine | Histamine Receptors | Selective, High Affinity H4 Agonist | 4Methylhistamine

Category:

Cat.No.	Product Name
2342	4-Methylhistamine dihydrochloride

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4-Methylhistamine

Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole

Biological Activity:

Potent, high affinity H₄ receptor agonist (K_i = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data:

M.Wt:	198.09
Formula:	C₆H₁₁N₃.2HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 50 mM in Water
CAS No:	[36376-47-3]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Lim et al (2005) Evaluation of histamine H₁-, H₂-, and H₃-receptor ligands at the human histamine H₄ receptor: identification of 4-methylhistamine as the first potent and selective H₄ receptor agonist. J.Pharmacol.Exp.Ther. 314 1310. Gbahou et al (2006) Compared pharmacology of human histamine H₃ and H₄ receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 744

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Keywords: 4-Methylhistamine, Histamine Receptors, Selective, High Affinity H4 Agonist, 4Methylhistamine, Tocris Bioscience

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Histamine Receptors
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