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Category:
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Cellular Processes and Components Cell CycleCell Cycle Inhibitors
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Cat.No.
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Product Name
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1230 |
Methotrexate
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Price and Availability
Click here for full price details of
Methotrexate
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Chemical Name:
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]ben
zoyl]-L-glutamic acid |
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Biological Activity:
Cytotoxic agent. Inhibits
thymidylate synthetase and de novo purine synthesis. Potent folic acid
antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl
methylation in DKOB8 cells, leading to decreased p44 and Akt activation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Jolivet et al (1983) The pharmacology and clinical use of
methotrexate. N.Engl.J.Med. 309 1094. Allegra et al
(1987) Evidence for direct inhibition of de novo protein synthesis in
human MCF-7 breast cells as a principal mode of metabolic inhibition by
methotrexate. J.Biol.Chem. 262 13520. Chu et al
(1990) Mechanism of thymidylate synthase inhibition by methotrexate in human
neoplastic cell lines and normal human myeloid progenitor cells. J.Biol.Chem. 265
8470. Winter-Vann et al (2003) Targeting Ras signaling through
inhibition of carboxyl methylation: an unexpected property of methotrexate.
Proc.Natl.Acad.Sci.USA 100 6529.
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View related products by Pharmacological Action
or by Research Area
Keywords: Methotrexate, Cell Cycle, Cytotoxic Agent, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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