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Category:
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7TM Receptors Adrenergic ReceptorsAlpha-2 ReceptorsAgonists
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Cat.No.
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Product Name
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2023 |
Medetomidine hydrochloride
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Price and Availability
Click here for full price details of
Medetomidine
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Chemical Name:
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
hydrochloride |
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Biological Activity:
Potent,
highly selective α2-adrenoceptor agonist (Ki
values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively).
Displays greater selectivity over α1-adrenoceptors than clonidine and UK
14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in
electrically stimulated mouse vas deferens (pD2 = 9.0). Active in
vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and
analgesic effects.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Savola et al (1986) Evidence for medetomidine as a selective and
potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 6 275. Virtanen
et al (1988) Characterization of the selectivity, specificity and
potency of medetomidine as an α2-adrenoceptor agonist.
Eur.J.Pharmacol. 150 9. Scheinin et al (1989)
Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic
effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635.
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Keywords: Medetomidine, Adrenergic Receptors, Potent, Highly Selective A2 Agonist, Tocris Bioscience
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