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Category:
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Transporters Neurotransmitter Transporters5-HT Transporters
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Cat.No.
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Product Name
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2148 |
(±)-McN 5652
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| Alternative name(s): |
McN 5652-Z |
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Price and Availability
Click here for full price details of
McN 5652, (+/-)
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Chemical Name:
(6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)
phenyl]-pyrrolo[2,1-a]isoquinoline |
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Biological Activity:
Potent, high affinity serotonin re-uptake
inhibitor that is selective in vivo. In vitro, displays moderate selectivity
over noradrenaline and dopamine re-uptake (Ki
values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenaline and
dopamine uptake respectively in rat brain synaptosomes). Potently potentiates
5-HT-induced effects in vivo following oral administration. Biological activity
resides predominantly in (+)-enantiomer.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Shank et
al (1988) McN-5652: a highly potent inhibitor of serotonin uptake.
J.Pharmacol.Exp.Ther. 247 1032. Maryanoff et al (1990)
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J.Med.Chem 33
2793. Smith et al (1991) Effects of pyrroloisoquinoline
enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological
serotonergic mechanisms in rats. Eur.J.Pharmacol. 196 85.
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Keywords: McN 5652, (+ / -), Neurotransmitter Transporters, Potent, Orally Active 5-HT Uptake Inhibitor. Also Inhibits Noradrenaline & Dopamine Uptake In Vitro, McN 5652-Z, McN5652, (+ / -), Tocris Bioscience
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