Alpha-MSH | Peptides (Hypothalamic / Pituitary Hormones) | Endogenous Melanocortin Receptor Agonist | A-Melanotropin | A-Melanocyte-stimulating Hormone

Category:

7TM Receptors

Peptides (Hypothalamic/Pituitary Hormones)

Melanocortin Receptors

Cat.No.

Product Name

2584

a-MSH

Alternative name(s):	a-Melanotropin
	a-Melanocyte-stimulating hormone

Price and Availability

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alpha-MSH

Biological Activity:

Endogenous melanocortin receptor agonist (K_i values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonises proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data:

M.Wt:	1664.9
Formula:	C₇₇H₁₀₉N₂₁O₁₉S
Storage:	Desiccate at -20°C
CAS No:	[581-05-5]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Wikberg (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295. Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757. Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429.

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Keywords: Alpha-MSH, Peptides (Hypothalamic / Pituitary Hormones), Endogenous Melanocortin Receptor Agonist, A-Melanotropin, A-Melanocyte-stimulating Hormone, Tocris Bioscience

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