Sold under
licence from the NIH, US Patent 10/169975
Chemical Name:[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9
-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl]
diphosphoric acid mono ester trisodium salt
Biological Activity:
Highly potent, selective P2Y1
receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12
receptors and only very low agonist activity at P2Y13 receptors (at
concentrations up to 1 μM).
Raviet al
(2002) Adenine nucleotide analogues locked in a northern methanocarba
conformation: enhanced stability and potency as P2Y1 receptor
agonists. J.Med.Chem. 45 2090. Chhatriwala et al
(2004) Induction of novel agonist selectivity for the ADP-activated P2Y1
receptor versus the ADP-activated P2Y12 and P2Y13
receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 311
1038.
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