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Category:
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7TM Receptors Glutamate (Metabotropic) ReceptorsGroup III mGlu ReceptorsAntagonists
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Cat.No.
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Product Name
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2963 |
MMPIP hydrochloride
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Price and Availability
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MMPIP hydrochloride
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Chemical Name:
6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[
4,5-c]pyridin-4(5H)-one hydrochloride |
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Biological Activity:
Potent allosteric mGlu7-selective
receptor antagonist. Inhibits agonist-induced intracellular calcium
mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM).
Displays intrinsic activity; increases forskolin-induced cAMP accumulation in
the absence of an agonist (IC50 = 15 nM), indicating inverse agonist
activity.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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For specific/earlier batch please select:
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References:
Suzuki et
al (2007) In vitro pharmacological characterization of novel
isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7
antagonists. J.Pharmacol.Exp.Ther. 323 147.
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or by Research Area
Keywords: MMPIP Hydrochloride, Glutamate (Metabotropic) Receptors, Potent, Allosteric MGlu7-selective Antagonist, Tocris Bioscience
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