(+)-MK 801 Maleate | Ligand-gated Ion Channels | Non-competitive NMDA Antagonist, Acts Ion Channel Site | Dizocilpine | MK801 Maleate

Category:

Ion Channels

Ligand-gated Ion Channels

Glutamate (Ionotropic) Receptors

NMDA Selective

Ion Channel

Cat.No.

Product Name

0924

(+)-MK 801 maleate

Alternative name(s):

Dizocilpine

(+)-MK 801 maleate
C16H15N.C4H4O4 (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate

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(+)-MK 801 maleate

Chemical Name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cycl ohepten-5,10-imine maleate

Biological Activity:

A potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca²⁺ flux. An effective anti-ischaemic agent in several animal models.

Technical Data:

M.Wt:	337.37
Formula:	C₁₆H₁₅N.C₄H₄O₄
Storage:	Store at RT
Solubility:	Soluble to 25 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[77086-22-7]

Resources:

Certificate of Analysis / MSDS:

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References:

Wong et al (1986) The anticonvulsant MK 801 is a potent NMDA antagonist. Proc.Natl.Acad.Sci.USA 83 7104. Gill et al (1991) The neuroprotective action of dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia. Br.J.Pharmacol. 103 2030. Hatfield et al (1992) The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur.J.Pharmacol. 216 1. Zajaczkowski et al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961.

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Keywords: (+)-MK 801 Maleate, Ligand-gated Ion Channels, Non-competitive NMDA Antagonist, Acts Ion Channel Site, Dizocilpine, MK801 Maleate, Tocris Bioscience

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