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Category:
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7TM Receptors Leukotriene Receptors
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Cat.No.
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Product Name
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2338 |
MK 571
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| Alternative name(s): |
L-660711 |
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Price and Availability
Click here for full price details of
MK 571
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Chemical Name:
3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][
[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propano
ic acid |
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Biological Activity:
Potent
CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50
= 1.3 nM). Antagonises LTD4-induced contractions of guinea pig
trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also
inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro
augments the effects of cytotoxic agents on malignant cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Vellenga et al (1999) Interleukin-6 production by activated human
monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug
resistance protein-1. Br.J.Pharmacol. 127 441. Blain and
Sirois (2000) Involvement of LTD4 in allergic pulmonary
inflammation in mice: modulation by cysLT1 antagonist MK-571.
Prost.Leuko.Essent.Fatty Acids 62 361. Dupre et al
(2004) Inverse agonist activity of selected ligands of the
cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 309 102.
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or by Research Area
Keywords: MK 571, Leukotriene Receptors, Potent CysLT1 (LTD4) Inverse Agonist. Also MRP Inhibitor, L-660711, MK571, Tocris Bioscience
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