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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT1 Receptorsarrow5-HT1A
Cat.No. Product Name
0411

MDL 73005EF hydrochloride  

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MDL 73005EF hydrochloride
Chemical Name: 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro [4.5]decane-7,9-dione hydrochloride

Biological Activity:

Potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.

Technical Data:

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M.Wt: 394.9
Formula: C20H26N2O4.HCl
Storage: Store at RT
Solubility: Soluble to 25 mM in Water
CAS No: [124756-23-6]

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    References:

    Gartside et al (1990) Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A  receptor function in the rat in vivo. Eur.J.Pharmacol. 191 391. Van der Hooff and Galvan (1991) Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. Eur.J.Pharmacol. 196 291. Buisson Defferier and Van den Buuse (1992) Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats. Eur.J.Pharmacol. 223 133.

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    Keywords: MDL 73005EF Hydrochloride, 5-HT Receptors, Potent & Selective 5-HT1A Partial Agonist, MDL73005EF Hydrochloride, Tocris Bioscience
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