3-MATIDA | Glutamate (Metabotropic) Receptors | Potent, Selective MGlu1 Antagonist | 3MATIDA

Category:

Cat.No.	Product Name
2196	3-MATIDA

Price and Availability

Click here for full price details of
3-MATIDA

Chemical Name: a-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid

Biological Activity:

Potent metabotropic glutamate mGlu₁ receptor antagonist (IC₅₀ = 6.3 μM at rat mGlu_1a). Displays ≥ 40-fold selectivity over other receptors: mGlu₅, mGlu₂, mGlu_4a (IC₅₀ > 300 μM), NMDA and AMPA (IC₅₀ = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.

Technical Data:

M.Wt:	215.23
Formula:	C₈H₉NO₄S
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in 1eq. NaOH
Purity:	>99%
CAS No:	[518357-51-2]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Moroni et al (2002) The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology 42 741. Cozzi et al (2002) Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology 43 119. Constantino et al (2004) Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist. Il Farmaco 59 93.

View related products by Pharmacological Action or by Research Area

Keywords: 3-MATIDA, Glutamate (Metabotropic) Receptors, Potent, Selective MGlu1 Antagonist, 3MATIDA, Tocris Bioscience

Literature in this Area

Scientific Reviews

Metabotropic Glutamate Receptors
Request Copy | Download PDF

The Ins & outs of Glutamate Transporter Pharmacology
Request Copy | Download PDF

Featured New Product

Selective AMPA antagonist

2701 YM 90K HCl

Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.

View all Featured New Products

New Products in this Area

	2963	MMPIP hydrochloride
	Potent, allosteric mGlu₇-selective antagonist
	2921	MTEP
	Potent, selective mGlu₅ antagonist
	2453	LY 379268
	Highly selective group II mGlu agonist
	2031	Anti-mGlu₇
	Antibody recognising human mGlu₇ receptors
	2032	Anti-mGlu₅
	Antibody recognising rat mGlu₅ receptors
	2029	Anti-mGlu_2/3
	Antibody recognising human mGlu₂ and mGlu₃ receptors
	2027	Anti-mGlu₂
	Antibody recognising rat mGlu₂ receptors

for new product e-alerts

User ID
Password