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Category: EnzymesarrowKinasesarrowMitochondrial Hexokinase
Cat.No. Product Name
1646 Lonidamine
Alternative name(s): AF 1890
Price and Availability

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Lonidamine
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid

Biological Activity:

Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.

Technical Data:

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M.Wt: 321.16
Formula: C15H10Cl2N2O2
Storage: Store at RT
Solubility: Soluble to 5 mM in Ethanol and to 100 mM in DMSO
Purity: >99%
CAS No: [50264-69-2]

Resources:

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    References:

    Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61. De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. Oncology 41 15. Teicher (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411. Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928.
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    Keywords: Lonidamine, Kinases, Mitochondrial Hexokinase Inhibitor, AF 1890, Tocris Bioscience
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