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Category:
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Transporters Neurotransmitter Transporters5-HT Transporters
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Cat.No.
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Product Name
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2545 |
Lofepramine
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| Alternative name(s): |
Lopramine |
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Leo 640 |
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Price and Availability
Click here for full price details of
Lofepramine
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Chemical Name:
1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]a
zepin-5-yl)propyl]methylamino]ethanone |
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Biological Activity:
Serotonin and noradrenaline re-uptake inhibitor
(SNRI) that is metabolised to desipramine. Produces inhibition of liver
tryptophan pyrollase activity in vitro and displays antidepressant properties
in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Leonard
(1987) A comparison
of the pharmacological properties of the novel tricyclic antidepressant
lofepramine with its major metabolite, desipramine: a review.
Int.Clin.Psychopharmacol. 2 281. Badawy et al
(1991) The effects of lofepramine and desmethylimipramine on tryptophan
metabolism and disposition in the rat. Biochem.Pharmacol. 42 921.
Kelly and Leonard (1999) An investigation of the antidepressant
properties of lofepramine and its desmethylated metabolites in the forced swim
and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol.
9 101.
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Keywords: Lofepramine, Neurotransmitter Transporters, 5-HT & Noradrenaline Re-uptake Inhibitor (SNRI), Lopramine, Leo 640, Tocris Bioscience
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