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Category:
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Ion Channels Potassium ChannelsATP-Activated Potassium Channels
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Cat.No.
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Product Name
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1378 |
Levcromakalim
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| Alternative name(s): |
BRL
38227 |
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Price and Availability
Click here for full price details of
Levcromakalim
Other Information:
Sold under
licence
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Chemical Name:
(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p
yrrolidinyl)-2H-1-benzopyran-6-carbonitrile |
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Biological Activity:
Active enantiomer of the prototypical KATP channel
opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50
= 490 nM in guinea pig trachea.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a
new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.
J.Med.Chem. 34 919. Noack et al (1992) Potassium
channel modulation in rat portal vein by ATP depletion: a comparison with the
effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945. Taylor
et al (1992) The inhibitory effects of cromakalim and its
active enantiomer BRL 38227 against various agonists in guinea pig and human
airways. J.Pharmacol.Exp.Ther. 261 429.
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View related products by Pharmacological Action
or by Research Area
Keywords: Levcromakalim, Potassium Channels, KATP Channel Opener. Active Enantiomer Of Cat. No. 1377, BRL 38227, Tocris Bioscience
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