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Category:
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Ion Channels Calcium ChannelsVoltage-gated Calcium Channels
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Cat.No.
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Product Name
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2959 |
Lercanidipine hydrochloride
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Price and Availability
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Lercanidipine
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Chemical Name:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine
dicarboxylic acid
2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl
methyl ester hydrochloride |
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Biological Activity:
L-type Ca2+ channel
blocker that displays higher vascular selectivity than Felodipine (Cat. No.
2960). Causes peripheral vasodilation with only weak negative inotropic
activity. Antihypertensive.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Sironi et al
(1996) Antihypertensive effects of lercanidipine in experimental hypertensive
rats and dogs. Arzneim.Forsch. 46 152. Bang et al
(2003) Lercanidipine. A review of its efficacy in the management of
hypertension. Drugs 63 2449. Wirtz and Herzig (2004)
Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine
lercanidipine. Br.J.Pharmacol. 142 275.
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Keywords: Lercanidipine, Calcium Channels, L-type Ca2+ Channel Blocker, Tocris Bioscience
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