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Category:
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7TM Receptors Leukotriene Receptors
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Cat.No.
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Product Name
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2140 |
LY 171883
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| Alternative name(s): |
Tomelukast |
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Price and Availability
Click here for full price details of
LY 171883
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Chemical Name:
1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phe
nyl]ethanone |
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Biological Activity:
Selective, orally active leukotriene D4 (LTD4)
antagonist; inhibits binding of [3H]-LTD4 to guinea pig
lung membranes (Ki = 0.63 μM). Acts as an
agonist at peroxisome proliferator-activated receptors (PPARs).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fleisch et al (1985) LY171883, 1-less than
2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl
greater than ethanone, an orally active leukotriene D4 antagonist.
J.Pharmacol.Exp.Ther. 233 148. Aharony et al (1987)
Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the
novel leukotriene antagonist ICI 198,615. J.Pharmacol.Exp.Ther. 243
921. Cannon and Eacho (1991) Interaction of LY171883 and other
peroxisome proliferators with fatty-acid-binding protein isolated from rat
liver. Biochem.J. 280 387.
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or by Research Area
Keywords: LY 171883, Leukotriene Receptors, Selective, Orally Active LTD4 Antagonist, Tomelukast, LY171883, Tocris Bioscience
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