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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT7 Receptors
Cat.No. Product Name
2534 LP 44
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LP 44

Other Information:

Sold under licence from the University of Bari
Chemical Name: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride

Biological Activity:

High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).

Technical Data:

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M.Wt: 488.13
Formula: C27H37N3OS.HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity: >98%
CAS No: [824958-12-5]

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    References:

    Leopoldo et al (2004) Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem. 47 6616.
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    Keywords: LP 44, 5-HT Receptors, High Affinity 5-HT7 Agonist, LP44, Tocris Bioscience
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