LOE 908 | Other Channel Modulators | Broad Spectrum Cation Channel Blocker; Neuroprotective | LOE908

Category:

Cat.No.	Product Name
2314	LOE 908 hydrochloride

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LOE 908

Chemical Name: 3,4-Dihydro-6,7-dimethoxy-a-phenyl-N,N-bis[2-(2,3,4-tri methoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride

Biological Activity:

Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na⁺ and K⁺ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

Technical Data:

M.Wt:	749.29
Formula:	C₄₁H₄₈N₂O₉.HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 50 mM in Water and to 100 mM in DMSO
Purity:	>98%
CAS No:	[149759-26-2]

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References:

Krause et al (1998) LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 244 659. Tatlisumak et al (2000) Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurolog.Sci. 178 107. Christensen et al (2005) The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 96 316.

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Keywords: LOE 908, Other Channel Modulators, Broad Spectrum Cation Channel Blocker; Neuroprotective, LOE908, Tocris Bioscience

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