Z-LEHD-FMK | Proteases | Cell-permeable Caspase-9 Inhibitor | ZLEHD-FMK

Category:

Cat.No.	Product Name
2171	Z-LEHD-FMK

Price and Availability

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Z-LEHD-FMK

Chemical Name: Benzyloxycarbonyl-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethy lketone

Biological Activity:

Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischaemia-reperfusion injury. Neuroprotective following cerebral ischaemia in rats in vivo.

Technical Data:

M.Wt:	690.72
Formula:	C₃₂H₄₃FN₆O₁₀
Storage:	Desiccate at -20°C
Solubility:	Soluble to 20 mM in DMSO

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Mocanu et al (2000) Capsase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br.J.Pharmacol. 130 197. Mouw et al (2002) Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. Metab.Brain Dis. 17 143. Bang et al (2004) Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659.

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Keywords: Z-LEHD-FMK, Proteases, Cell-permeable Caspase-9 Inhibitor, ZLEHD-FMK, Tocris Bioscience

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