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Category:
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7TM Receptors Cannabinoid ReceptorsCB2 Receptors
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Cat.No.
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Product Name
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2433 |
L-759,633
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Price and Availability
Click here for full price details of
L-759633
Other Information:
Local regulations may restrict the sale of this
product in some countries: Canadian customers require a CDSA import permit
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Chemical Name:
(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydr
o-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran |
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Biological Activity:
High affinity, selective CB2 receptor agonist (Ki
values are 6.4 and 1043 nM for CB2 and CB1 receptors
respectively). Potently inhibits forskolin-stimulated cAMP production via CB2
receptors expressed in CHO cells (EC50 = 8.1 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ross et al (1999) Agonist-inverse agonist characterization at
CB1 and CB2 cannabinoid receptors of L759633, L759656 and
AM630. Br.J.Pharmacol. 126 665. Huffman et al
(1999) 3-(1',1'-dimethylbutyl)-1-deoxy-D8-THC and related
compounds: synthesis of selective ligands for the CB2 receptor.
Bioorg.Med.Chem. 7 2905. Huffman (2000) The search for
selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6
1323.
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or by Research Area
Keywords: L-759633, Cannabinoid Receptors, High Affinity, Selective CB2 Agonist, L759633, Tocris Bioscience
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