L-701,324 | Ligand-gated Ion Channels | NMDA Antagonist, Acts Glycine Site | L701,324

Category:

Ion Channels

Ligand-gated Ion Channels

Glutamate (Ionotropic) Receptors

NMDA Selective

Glycine Site

Antagonists

Cat.No.	Product Name
0907	L-701,324

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L-701,324

Other Information:

Sold with the permission of Merck Sharp and Dohme Ltd

Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinon e

Biological Activity:

An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

Technical Data:

M.Wt:	363.8
Formula:	C₂₁H₁₄CINO₃
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
Purity:	>99%
CAS No:	[142326-59-8]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

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References:

Kulagowski et al (1994) 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 37 1402. Obrenovitch and Zilkha (1996) Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex. Br.J.Pharmacol. 117 931. Bristow et al (1996) The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 277 578. Bristow et al (1996) Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J.Pharmacol.Exp.Ther. 279 492.

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Keywords: L-701,324, Ligand-gated Ion Channels, NMDA Antagonist, Acts Glycine Site, L701,324, Tocris Bioscience

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