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Category:
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7TM Receptors Prostanoid Receptors
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Cat.No.
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Product Name
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1698 |
L-655,240
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Price and Availability
Click here for full price details of
L-655240
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Chemical Name:
1-[(4-Chlorophenyl)methyl]-5-fluoro-a,a,3-trimethyl-1H-
indole-2-propanoic acid |
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Biological Activity:
Potent
and selective thromboxane A2/prostaglandin endoperoxide receptor
antagonist. pA2 values are 8-8.4 in guinea pig smooth muscle; IC50
= 7 nM for inhibition of human platelet aggregation. Orally active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hall et al (1987) Pharmacology of
L-655,240
(3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic
acid); a potent, selective thomboxane / prostaglandin endoperoxide antagonist.
Eur.J.Pharmacol. 135 193. Wainright and Parratt (1988) The
effects of L655,240, a selective thromboxane and prostaglandin endoperoxide
antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias.
J.Cardiovasc.Pharmacol. 12 264. Ogletree and Allen (1992)
Interspecies differences in thromboxane receptors: studies with thromboxane
receptor antagonists in rat and guinea pig smooth muscles.
J.Pharmacol.Exp.Ther. 260 789.
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Keywords: L-655240, Prostanoid Receptors, Potent, Selective Thromboxane A2 / Prostaglandin Endoperoxide Antagonist, L655240, Tocris Bioscience
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