Ketanserin Tartrate | 5-HT Receptors | Selective 5-HT2A Antagonist. Also Antagonist At 5-HT1D | R 41 468

Category:

7TM Receptors

5-HT Receptors

5-HT2 Receptors

5-HT2A

Cat.No.

Product Name

0908

Ketanserin tartrate

Alternative name(s):

R 41 468

Ketanserin tartrate
C22H22FN3O3.C4H6O6 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate

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Ketanserin tartrate

Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3 H]-quinazolinedione tartrate

Biological Activity:

Selective 5-HT_2A serotonin receptor antagonist; can also be used to discriminate between 5-HT_1Dand 5-HT_1B receptor subtypes.

Technical Data:

M.Wt:	545.52
Formula:	C₂₂H₂₂FN₃O₃.C₄H₆O₆
Storage:	Store at RT
Solubility:	Soluble to 10 mM in Water
Purity:	>97%
CAS No:	[83846-83-7]

Resources:

Certificate of Analysis / MSDS:

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References:

Leyson et al (1981) Receptor binding profile of R41 468, a novel antagonist at 5-HT₂ receptors. Life Sci. 28 1015. Van Nueten et al (1981) Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors. J.Pharmacol.Exp.Ther. 218 217. Razzaque et al (1995) Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur.J.Pharmacol. 283 199. Zgombick et al (1995) Ketanserin and ritanserin discriminate between recombinant human 5-HT1Da and 5-HT1Db receptor subtypes. Eur.J.Pharmacol.Mol.Pharmacol.Sect. 291 9.

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Keywords: Ketanserin Tartrate, 5-HT Receptors, Selective 5-HT2A Antagonist. Also Antagonist At 5-HT1D, R 41 468, Tocris Bioscience

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Scientific Reviews

5-HT Receptors & their Ligands
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