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Category:
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Cellular Processes and Components Extracellular Matrix and Adhesion MoleculesAdhesion Molecules
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Cat.No.
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Product Name
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2748 |
KF 38789
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Price and Availability
Click here for full price details of
KF 38789
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Chemical Name:
3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiaz
epin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one |
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Biological Activity:
Selective inhibitor of P-selectin-mediated cell
adhesion (IC50 = 1.97 μM) that
displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks
P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Haggerty et al
(2000) Dissecting cellular processes using small molecules: identification of
colchicine-like, taxol-like and other small moleculaes that perturb mitosis.
Chem.Biol. 7 275. Ohta et al (2001) Inhibition of
P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate
compound, KF38779. Inflamm.Res. 50 544. Kaila et al (2007)
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin
antagonists. J.Med.Chem. 50 21.
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View related products by Pharmacological Action
or by Research Area
Keywords: KF 38789, Extracellular Matrix & Adhesion Molecules, Selective Inhibitor Of P-selectin-mediated Cell Adhesion, KF38789, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
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