JX 401 | Kinases | Potent, Reversible P38a Inhibitor | JX401

Category:

Cat.No.	Product Name
2657	JX 401

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JX 401

Chemical Name: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)pip eridine

Biological Activity:

Potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC₅₀ values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

Technical Data:

M.Wt:	355.49
Formula:	C₂₁H₂₅NO₂S
Storage:	Store at RT
Solubility:	Soluble to 75 mM in DMSO and to 50 mM in Ethanol
Purity:	>99%
CAS No:	[349087-34-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395.

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Keywords: JX 401, Kinases, Potent, Reversible P38a Inhibitor, JX401, Tocris Bioscience

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