JP 1302 | Adrenergic Receptors | Potent & Selective A2C Antagonist | JP1302

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Cat.No.	Product Name
2666	JP 1302 dihydrochloride

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JP 1302

Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

Biological Activity:

α_2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α₂-adrenoceptor subtypes (K_i values are 28, 1470, 1700 and 3150 nM for human α_2C, α_2B, α_2D and α_2A subtypes respectively). Potently antagonises adrenalin-stimulated ³⁵GTPγS binding in vitro (K_B = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Technical Data:

M.Wt:	441.4
Formula:	C₂₄H₂₄N₄.2HCl
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in Water and to 5 mM in DMSO
Purity:	>99%
CAS No:	[80259-18-3]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Tricklebank (2007) JP-1302: a new tool to shed light on the roles of α_2C-adrenoceptors in brain. Br.J.Pharmacol. 150 381. Sallinen et al (2007) Pharmacological characterization and CNS effects of a novel highly selective α_2C-adrenoceptor antagonist JP-1302. Br.J.Pharmacol. 150 391.

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Keywords: JP 1302, Adrenergic Receptors, Potent & Selective A2C Antagonist, JP1302, Tocris Bioscience

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Adrenoceptor Pharmacology
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