JLK 6 | Proteases | Inhibitor Of G-secretase-mediated BAPP Processing | JLK6

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Cat.No.	Product Name
2677	JLK 6

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JLK 6

Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran

Biological Activity:

Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC₅₀ ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signalling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.

Technical Data:

M.Wt:	225.63
Formula:	C₁₀H₈ClNO₃
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity:	>99%
CAS No:	[62252-26-0]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Petit et al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507. Petit et al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370. Hellstrom et al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776.

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Keywords: JLK 6, Proteases, Inhibitor Of G-secretase-mediated BAPP Processing, JLK6, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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Product Feature

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Reduces Aβ40 & Aβ42 levels in human primary neuronal cultures

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Selectively inhibits βAPP cleavage

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Decreases released levels of Aβ42 & Nβ25

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