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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowMiscellaneous Glutamate
Cat.No. Product Name
1260 Ivermectin
Price and Availability

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Ivermectin
Chemical Name: 22,23-Dihydroavermectin B1

Biological Activity:

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

Technical Data:

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M.Wt: 875.1
Formula: C48H74O14(B1a form)
Storage: Desiccate at +4°C
Solubility: Soluble to 50 mM in DMSO
CAS No: [70288-86-7]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Merck Index 12 5264. Krause et al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283. Khakh et al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289. Adelsberger et al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin. Eur.J.Pharmacol. 394 163. Shan et al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556.
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    Keywords: Ivermectin, Ligand-gated Ion Channels, Modulates Glutamate / GABA-activated CI- Channels, Tocris Bioscience
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