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Category:
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Enzymes ProteasesCaspase
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Cat.No.
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Product Name
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2636 |
Ivachtin
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Price and Availability
Click here for full price details of
Ivachtin
Other Information:
Sold with the permission of ChemDiv, Inc.
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Chemical Name:
2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-di
hydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate |
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Biological Activity:
Potent, reversible inhibitor of caspase-3 (IC50
= 23 nM) that displays moderate selectivity over other caspases. Exhibits
antiapoptotic activity in human Jurkat T cells treated with staurosporine;
exhibits a higher level of protection than Z-VAD-FMK (Cat. No. 2163).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Kravchenko et al
(2005) Synthesis and structure-activity relationship of 4-substituted
2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones
as potent caspase-3 inhibitors. J.Med.Chem. 48 3680.
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View related products by Pharmacological Action
or by Research Area
Keywords: Ivachtin, Proteases, Potent Caspase-3 Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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