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Category:
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Enzymes Phosphodiesterases
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Cat.No.
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Product Name
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2504 |
Irsogladine maleate
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| Alternative name(s): |
MN 1695 |
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Price and Availability
Click here for full price details of
Irsogladine
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Chemical Name:
6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine
maleate |
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Biological Activity:
Phosphodiesterase
4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric
mucosal injury induced by monochloramine and ischemia-reperfusion. Activates
gap-junctional intercellular communication improving gastric mucosal barrier
function. Inhibits superoxide production in human neutrophils and inhibits in
vitro and in vivo angiogenesis.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Nozaki et al (2004) Inhibition of
breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric
ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195. Kyoi
et al (2004) Phosphodiesterase type IV inhibitors prevent
ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95
321. Kyoi et al (2004) Irsogladine, an anti-ulcer drug,
suppresses superoxide production by inhibiting phosphodiesterase type 4 in
human neutrophils. Life Sci. 76 71.
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View related products by Pharmacological Action
or by Research Area
Keywords: Irsogladine, Phosphodiesterases, PDE4 Inhibitor; Antiulcer Agent, MN 1695, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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