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Immepip dihydrobromide
Chemical Name:4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Biological Activity:
Potent histamine H3 receptor
agonist. Also binds to H4 receptors (Ki values are 0.4
and 9 nM at human recombinant H3 and H4 receptors
respectively). Equipotent to or slightly more active than (R)-α-methylhistamine
at H3 receptors.
Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist.
J.Med.Chem. 37 332. Coruzzi et al (1995)
Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the
anaesthetized rat. Naunyn-Schmied.Arch.Pharmacol. 351 569. Liu
et al (2001) Cloning and pharmacological characterization of a fourth
histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59
420.
