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Category:
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7TM Receptors Prostanoid Receptors
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Cat.No.
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Product Name
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2038 |
Iloprost
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| Alternative name(s): |
ZK 36374 |
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Price and Availability
Click here for full price details of
Iloprost
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Chemical Name:
(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-
3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenyliden
e]pentanoic acid |
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Biological Activity:
Prostacyclin (PGI2)
analogue that binds with high affinity to IP, EP1 and EP3
receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487
nM for IP, EP1, EP3, EP4, FP, DP, EP2
and TP receptors respectively). Inhibits platelet aggregation induced by
collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM
respectively).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Schror et
al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin
derivative (ZK 36 374) - equipotent to PGI2 in vitro.
Naunyn-Schmied.Arch.Pharmacol. 316 252. Della Bella et
al (2001) Novel mode of action of iloprost: in vitro down-regulaton of
endothelial cell adhesion molecules. Prostaglandins.Other Lipid Mediat. 65
73. Abramovitz et al (2000) The utilization of recombinant
prostanoid receptors to determine the affinities and selectivities of
prostaglandins and related analogs. Biochim.Biophys.Acta 1483
285.
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View related products by Pharmacological Action
or by Research Area
Keywords: Iloprost, Prostanoid Receptors, Prostacyclin (PGI2) Analogue, ZK 36374, Tocris Bioscience
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