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Category:
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Enzymes Phosphodiesterases
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Cat.No.
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Product Name
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1694 |
Ibudilast
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| Alternative name(s): |
KC-404 |
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Price and Availability
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Ibudilast
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Chemical Name:
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-y
l]-1-propanone |
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Biological Activity:
Phosphodiesterase
inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V
respectively). Inhibits platelet aggregation and is an orally-active cerebral
vasodilator, bronchodilator and anti-allergic agent.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Nishino et al (1983) KC-404: a
potential anti-allergic agent with antagonistic action against slow reacting
substance of anaphylaxis. Jpn.J.Pharmacol. 33 267. Souness
et al (1994) Possible role of cyclic AMP phosphodiesterases in the
actions of ibudilast on eosinophil thromboxane generation and airways smooth
muscle tone. Br.J.Pharmacol. 111 1081. Kishi et al
(2001) Ibudilast: a non-selective PDE inhibitor with multiple actions on blood
cells and the vascular wall. Cardiovasc.Drug Rev. 19 215.
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View related products by Pharmacological Action
or by Research Area
Keywords: Ibudilast, Phosphodiesterases, PDE Inhibitor (non-selective), KC-404, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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