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Category:
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Enzymes PhosphatasesPP
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Cat.No.
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Product Name
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2162 |
INCA-6
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Price and Availability
Click here for full price details of
INCA-6
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Chemical Name:
9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione |
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Biological Activity:
Inhibitor
of interaction between calcineurin and its substrate nuclear factor of
activated T cells (NFAT); blocks at the substrate recognition site but not at
the catalytic site (Kd = 0.8 μM). Inhibits NFAT dephosphorylation
and nuclear import. Also prevents induction of cytokine mRNAs that are
downstream targets of NFAT.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Roehrl et al (2004) Selective inhibition of
calcineurin-NFAT signaling by blocking protein-protein interaction with small
organic molecules. Proc.Natl.Acad.Sci.USA 101 7554.
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View related products by Pharmacological Action
or by Research Area
Keywords: INCA-6, Phosphatases, Inhibitor Of Calcineurin-substrate Association, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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