Z-IETD-FMK | Proteases | Caspase-8 Inhibitor | ZIETD-FMK

Category:

Cat.No.	Product Name
2170	Z-IETD-FMK

Price and Availability

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Z-IETD-FMK

Chemical Name: Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethy lketone

Biological Activity:

Inhibitor of caspase-8. Blocks TNFα-induced cytochrome c release and apoptosis in human leukemic U937 cells. Also inhibits nuclear protein cleavage in Jurkat, MCF-7 and HeLa cells in vitro.

Technical Data:

M.Wt:	654.69
Formula:	C₃₀H₄₃FN₄O₁₁
Storage:	Store at -20°C
Solubility:	Soluble to 20 mM in DMSO

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Partheniou et al (2001) c-IAP1 blocks TNFα-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells. Biochem.Biophys.Res.Comm. 287 181. Taimen and Kallajoki (2003) NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J.Cell Sci. 116 571. Bang et al (2004) Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659.

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Keywords: Z-IETD-FMK, Proteases, Caspase-8 Inhibitor, ZIETD-FMK, Tocris Bioscience

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