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Category:
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7TM Receptors Nicotinic Acid Receptors (GPR109)
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Cat.No.
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Product Name
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2469 |
IBC 293
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Price and Availability
Click here for full price details of
IBC 293
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Chemical Name:
1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid |
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Biological Activity:
Highly selective agonist for GPR109b (HM74), the
human orphan G-protein-coupled receptor expressed in adipocytes. Selective for
GPR109b over closely related niacin receptor GPR109a (HM74A); EC50
values are 400 nM and > 1 μM
respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated
human adipocytes.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Semple et al (2006)
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the
human orphan G-protein-coupled receptor GPR109b. J.Med.Chem. 49
1227.
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View related products by Pharmacological Action
or by Research Area
Keywords: IBC 293, Nicotinic Acid Receptors (GPR109), Selective Agonist For The GPR109b (HM74) Receptor. Antilipolytic, IBC293, Tocris Bioscience
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| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
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