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Hemokinin 1 (human)
Biological Activity:
Endogenous substance P homologue that is a
selective agonist at the tachykinin NK1 receptor (IC50
values are 1.8, 370 and 480 nM respectively). Has proliferative and
anti-apoptotic actions on B-cells in vitro and is antihypertensive in vivo.
Zhanget al (2000)
Hemokinin is a hematopoietic-specific tachykinin that regulates B
lymphopoiesis. Nature Immunol. 1 392. Bellucciet al (2002)
Pharmacological profile of the novel mammalian tachykinin hemokinin 1.
Br.J.Pharmacol. 135 266. Kurtzet al (2002)
Identification, localization and receptor characterization of novel mammalian
substance P-like peptides. Gene 296 205.
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