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Category: EnzymesarrowKinasesarrowProtein Kinase A
Cat.No. Product Name
2910 H 89 dihydrochloride
Price and Availability

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H 89 dihydrochloride
Chemical Name: N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoq uinolinesulfonamide dihydrochloride

Biological Activity:

Protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b.

Technical Data:

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M.Wt: 519.28
Formula: C20H20BrN3O2S.2HCl
Storage: Store at -20°C
Solubility: Soluble to 25 mM in Water and to 100 mM in DMSO
Purity: >99%
CAS No: [127243-85-0]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Vitolo et al (2002) Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proct.Natl.Acad.Sci.USA 99 13217. Lochner and Moolman (2006) The many faces of H89: a review. Cardiovasc.Drug Rev. 24 261. Yamada et al (2006) Involvement of cAMP response element-binding protein activation in salivary secretion. Pathobiology 73 1.
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    Keywords: H 89 Dihydrochloride, Kinases, Protein Kinase A Inhibitor, H89 Dihydrochloride, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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